martes, 11 de enero de 2011

INfLAmmAtION Directions from the matrix

Emerging evidence reveals that components of the extracellular matrix can directly regulate inflammatory processes. Now, researchers have identified a role for the matrix component biglycan in the pathogenesis of lupus nephritis through its ability to induce expression of the B cell chemoattractant CXC-chemokine ligand 13 (CXCL13).

References

NaTuRE REvIEWS | Immunology vOLuME 11 | jaNuaRy 2011

ORIGINAL RESEARCH PAPER Moreth, K. et al.
The proteoglycan biglycan regulates expression
of the B cell chemoattractant CXCL13 and
aggravates murine lupus nephritis. J. Clin. Invest.
120, 4251–4272 (2010)