Emerging evidence reveals that components of the extracellular matrix can directly regulate inflammatory processes. Now, researchers have identified a role for the matrix component biglycan in the pathogenesis of lupus nephritis through its ability to induce expression of the B cell chemoattractant CXC-chemokine ligand 13 (CXCL13).References
NaTuRE REvIEWS | Immunology vOLuME 11 | jaNuaRy 2011
ORIGINAL RESEARCH PAPER Moreth, K. et al.
The proteoglycan biglycan regulates expression
of the B cell chemoattractant CXCL13 and
aggravates murine lupus nephritis. J. Clin. Invest.
120, 4251–4272 (2010)
NaTuRE REvIEWS | Immunology vOLuME 11 | jaNuaRy 2011
ORIGINAL RESEARCH PAPER Moreth, K. et al.
The proteoglycan biglycan regulates expression
of the B cell chemoattractant CXCL13 and
aggravates murine lupus nephritis. J. Clin. Invest.
120, 4251–4272 (2010)
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